In this, the 4th Nature Conference on the general theme of “flexible electronics”, we will focus on how these emerging technologies can facilitate the understanding of human disease or physiological conditions, or more generally be applied to facilitate improvements in human health and wellbeing. The program will cover sessions on electronic devices/materials for sensing and modulation of biological systems, wearable and implantable technologies for healthcare, AI-powered medical devices, and brain-computer interface. The goal is to bring together experts from materials science and engineering, biomedical engineering, computational science and clinicians to foster thoughtful discussion, debate and collaboration for the advancement of biologically and biomedically relevant research in flexible electronics and beyond.